Miscarriage occurs in 10 to 20% of known pregnancies. Most are called unexplained. But your MTHFR and FOXP3 gene variants may hold the explanation your doctors couldn’t give you, and the information you need to protect your next pregnancy.
You are not alone. More women have been here than you know.
Part of the 5-panel report. Also covers PCOS, depression, bone health and arthritis risk. Tested by NABL-accredited Neotech World Lab.
Real women, telling real stories, so the woman reading this knows that what happened to her is common, is not her fault, and is not always unexplainable.
She spoke about pregnancy loss not to generate sympathy, but because silence makes grief heavier, and because women who have been here deserve to know they are not alone, and that what happened to them is not their fault.
Pregnancy loss is not a failure of the woman. Often it is a convergence of genetic factors no amount of rest or willpower could change.
She wrote about two miscarriages: “I felt like I failed, because I didn’t know how common miscarriages were.” One of the most high-achieving, health-conscious women in the world. And she didn’t know.
Miscarriage is common, is often genetic, and with the right information is sometimes preventable. This test gives you that information.
Her public sharing changed the conversation globally. Women who had been suffering in silence suddenly saw their experience reflected back at them, and felt less alone, less ashamed, less broken.
You are not broken. You may have a genetic variant. And that is something science can work with.
Pregnancy loss is not rare. It is not your fault. And in many cases, it is not unexplainable. Your genes may hold the answer that your doctors couldn’t give you.
Now readable from a saliva sample.
The MTHFR gene controls an enzyme that converts folate into the active form your body can use. Folate is essential for foetal neural tube development, the early formation of the brain and spine that happens in the first weeks of pregnancy, often before a woman even knows she is pregnant.
A variant can impair this conversion, leading to elevated homocysteine levels, which is associated with recurrent pregnancy loss. It is particularly common and particularly underdiagnosed. Women with an MTHFR variant often need a different form of folate (methylfolate, not folic acid), a small change with a potentially significant impact.
The FOXP3 gene is involved in immune regulation, specifically the T-regulatory cells that prevent the immune system from attacking the body’s own tissues. During pregnancy, the mother’s immune system must tolerate the foetus, which carries paternal DNA it would otherwise recognise as foreign.
Defects in FOXP3 are associated with autoimmune dysfunction, and autoimmune causes are one of the leading explanations for otherwise unexplained recurrent pregnancy loss. Knowing your FOXP3 variant gives your doctor a critical piece of the immunological picture.
Most women with recurrent pregnancy loss are told it is bad luck. For many, it is actually a folate metabolism issue or an immune regulation variant, both identifiable, and both manageable with the right medical support.
The best time to take this test is before you start trying. Before the emotional investment. Before the first positive test. Before the first appointment.
Because if your MTHFR variant is present, your pre-conception supplementation protocol should change. Standard folic acid may not be enough, you may need active methylfolate. That is a conversation your doctor can have with you before your first cycle of trying, not after your third loss.
And if your FOXP3 variant shows autoimmune risk, your fertility specialist can factor that in from the beginning, monitoring immune markers, considering progesterone support, and preparing for the pregnancy rather than reacting to it.
This test is not about looking back. It’s about looking forward with better information. It will not undo what happened. But it may explain it, and it may make everything that comes next more possible.
Pre-conception genetic testing is not paranoia. It is the most rational, loving thing you can do for a pregnancy that hasn’t happened yet.
The pregnancy loss panel is Panel 02 of your Women’s Health DNA report. You’ll receive:
Your report also covers PCOS, post-pregnancy depression, osteoporosis and arthritis risk. All from one saliva sample. All in one 32-page report.
Your genotype is associated with normal risk of pregnancy loss. Eat healthy food. Exercise regularly to stay fit and healthy.
Sample shows a Good result. Your actual result will be unique to your genetic profile. A Poor result is the most actionable, it gives your doctor the specific direction they need.
of known pregnancies end in miscarriage
happen in the first trimester, often before a heartbeat is confirmed
of couples experience recurrent loss (3+ miscarriages)
of recurrent losses remain ‘unexplained’ by standard testing
one of the most common Indian genetic variants, one of the least tested
protocol adjusted pre-conception can significantly improve outcomes for carriers
a leading but underdiagnosed cause of unexplained pregnancy loss
from saliva sample to your complete 32-page report
First miscarriage at 9 weeks. Told it was ‘one of those things.’ Try again.
MTHFR variant identified. Standard folic acid replaced with active methylfolate. Pre-conception protocol changed. Next pregnancy ongoing.
Three pregnancy losses. Different doctors. Same answer: unexplained. ‘Your tests are all normal.’
FOXP3 variant flagged. Autoimmune cause identified. Fertility specialist adds immune monitoring and progesterone support. She is now 20 weeks.
Planning first pregnancy. Worried about family history of miscarriage. No one could tell her her own risk.
MTHFR and FOXP3 both normal. She goes into her first pregnancy informed. Confident. Prepared.
Spent ₹1.8 lakh on two IVF cycles before anyone mentioned genetics.
Genetic panel done first. MTHFR variant found. Protocol adjusted. Third embryo transfer successful. She wishes someone had suggested the test before cycle one.
Each line speaks to a different woman. Tap the ones that sound like you, and see where it leads.
Whatever you select stays on your device. Nothing is submitted, this is just for you.
Tap the statements that sound like you.
You’re not trying yet. But you’re thinking about it. Knowing your MTHFR status now means your supplementation is right from cycle one, not adjusted after a heartbreaking first trimester.
The highest-stakes window. If conception is taking longer, or a first pregnancy ended in loss, your genetic profile gives your doctor something concrete to act on. Not ‘let’s wait and see.’
Age raises loss risk on its own. Knowing whether you also carry a variant that compounds it changes how your doctor manages your next pregnancy. Earlier monitoring, immune support if needed.
Every cycle matters more. Every piece of information matters more. Your genetic pregnancy profile is one of the most valuable tools available to your fertility specialist at this stage.
“Two miscarriages. No explanation. My OB-GYN said my tests were all normal. I took the test because I needed more than normal. My MTHFR result showed a variant. My doctor changed my folate supplementation immediately. I am now 24 weeks with my third pregnancy. I am in it with more information than I’ve ever had.”
Meera S., 32Bengaluru · Architect“I took this test before my first pregnancy because my mother had two miscarriages. I wanted to know before I started trying. My MTHFR came back normal. My FOXP3 came back normal. I cannot describe what it felt like to go into my first pregnancy without the fear I had been carrying. This test gave me that.”
Tanya K., 28Delhi · Product manager“We had done two rounds of IVF. Both failed. Nobody mentioned genetics. My husband found the KYG test. My FOXP3 result showed an immune regulation variant. My fertility doctor called it a ‘missing piece.’ We’re doing a third round now with immunotherapy support added. I feel like we’re finally playing with the full picture.”
Priya R., 35Mumbai · EntrepreneurMost women with an MTHFR variant have been taking standard folic acid during pre-conception and pregnancy. Standard folic acid does not work the same way for MTHFR carriers. Methylfolate does. A simple, inexpensive switch that most women never make, because no one told them to test.
Most women whose FOXP3 variant causes immune-related loss are told it is unexplained. Because without the genetic context, it is. With it, it has a name, a mechanism, and a treatment pathway.
You cannot go back. But you can go forward with more than you had.
Saliva collection tube, instructions, prepaid return courier. Arrives in 2 to 3 days. Takes 2 minutes. No needle. No hospital. No appointment.
Neotech World Lab, NABL accredited, ISO 9001:2015 and ISO 27001:2013 certified, using Illumina SNP genotyping. Reviewed by Dr. Varun Sharma, Ph.D before release.
32-page personalised report in 7 days. Pregnancy panel plus 4 more. Plus a free 30-minute counselling session with a genetic counsellor who will answer every question, with specific next steps for your situation.
Every report manually reviewed by Dr. Varun Sharma, Ph.D, Scientist, Human Genetics.
Tested by Neotech World Lab Pvt. Ltd., MG Road, Gurugram, Haryana.
Technology: Illumina Infinium SNP array · 99%+ reproducibility · >98% call rate.
Your data is yours. Never sold, never shared. Sample destroyed after processing.
It can point to a likely genetic contributor. If you carry an MTHFR or FOXP3 variant, that is often the piece standard testing misses, the difference between “unexplained” and a cause your doctor can act on. It will not explain every loss, but for many women it explains theirs.
You can, and the result is still useful, but this test is most powerful taken before conception, when supplementation and monitoring can be adjusted from the start. If you are already pregnant, share the result with your doctor so they can factor it into your care right away.
Your report explains exactly what the variant means and what to discuss with your doctor, typically switching from standard folic acid to active methylfolate and monitoring homocysteine. Your free counselling session walks you through it, and your gynaecologist makes the final call.
Pregnancy loss risk is assessed from your genetics, so this panel is for you. But recurrent loss can involve both partners, your partner can take the Men’s Health DNA panel, and the ‘Know Before You Begin’ bundle covers both with a joint counselling session.
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Pregnancy loss panel, plus PCOS, depression, bone health and arthritis. All from one saliva kit. All in 7 days. With a genetic counsellor to walk you through every result.
The ‘Know Before You Begin’ bundle covers both partners, Women’s Health plus Men’s Health plus a joint counselling session. The most complete pre-conception genetic picture a couple can have.
“Your genes don’t change, and knowing what is in your genes can help you take better care of your health.”
